Brand name: Septra (GSK), Bactrim (Roche)
Drug class: Sulfonamide antibiotic
Trimethoprim inhibits the synthesis of nucleic acids and proteins in susceptible bacteria; the bacterial enzyme involved in this reaction is more readily inhibited than the mammalian enzyme.
Sulfamethoxazole acts as a false-substrate inhibitor of dihydropteroate synthetase. Sulfonamides such as sulfamethoxazole are analogues of p-aminobenzoic acid (PABA) and are competitive inhibitors of the enzyme; inhibiting the production of dihydropteroic acid.
- Uncomplicated UTIs caused by susceptible strains of Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species, and coagulase-negative Staphylococcus species, including S. Saprophyticus.
- Treatment of acute otitis media due to susceptible strains of S. Pneumoniae and Haemophilus influenzae in children.
- Unlabeled uses: With dapsone for treatment of initial episodes of Pneumocystis jiroveci (carinii) pneumonia in patients who can tolerate co-trimoxazole; treatment and prevention of traveller’s diarrhea.
- Contraindicated with allergy to trimethoprim and sulfamethoxazole, pregnancy (teratogenic in pre-clinical studies), megaloblastic anemia due to folate deficiency.
- Use cautiously with hepatic or renal impairment, lactation.
Tablets – 100, 200 mg
- Epigastric distress
- Perform culture and sensitivity tests before beginning drug therapy.
- Protect the 200mg tablets from exposure to light.
- Arrange for regular, periodic blood counts during therapy.
- Discontinue drug and consult with physician if any significant reduction in any formed blood element occurs.
cotrimoxazole drug study, co trimoxazole drug study, cotrimoxazole, drug study of cotrimoxazole, co-trimoxazole drug study, nursing considerations for trimethoprim, direct hiring of filipino nurses in germany