Hirschsprung Disease (Aganglionic Megacolon)
Congenital aganglionic megacolon, also called Hirschsprung disease, is characterized by persistent constipation resulting from partial or complete intestinal obstruction of mechanical origin.
Hirschsprung disease
Down Syndrome (Trisomy 21)
Down Syndrome is primarily caused by trisomy of chromosome 21, which gives rise to multiple systemic complications as part of the syndrome.