Drugs Study
Drugs for drug studies
Bupivacaine HCl Drug Study
Local anesthetics such as bupivacaine block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia More >
Mirtazapine
Mechanism of action unknown; appears to act similarly to TCAs, which inhibit the presynaptic reuptake of the neurotransmitters norepinephrine and serotonin;anticholinergic at CNS and peripheral receptors; sedating; relation of these effects to clinical efficacy is unknown.
Generic Name: mirtazapine
Brand Name: Remeron, Remeron SolTab
Other Info: Pregnancy Category C
Drug class: Antidepressant (tetracyclic)
Indication- Relief of symptoms of depression (endogenous depression most responsive)
Fluoxentine HCl (Prozac)
Acts as an antidepressant by inhibiting CNS neuronal uptake of serotonin; blocks uptake of serotonin with little effect on norepinephrine; little affinity for muscarinic, histaminergic, and alpha1-adrenergic receptors.
Generic Name: fluoxetine hydrochloride
Brand Name: Apo-Fluoxetine (CAN), Co-Fluoxetine (CAN), Novo-Fluoxetine (CAN), PMS-Fluoxetine (CAN), Prozac, Prozac Pulvules, Prozac Weekly, ratio-Fluoxetine (CAN), Sarafem
Other Info: Pregnancy More >
Escitalopram
Generic Name: escitalopram oxalate
Brand Name: Lexapro
Other Info: Pregnancy Category C
Drug classes: Antidepressant, SSRI
Therapeutic actionsPotentiates serotonergic activitity in the CNS by inhibiting reuptake of serotonin resulting in antidepressant effect with little effect on norepinephrine or dopamine; an isomer of citalopram.
Indications- Treatment of major depressive disorder
- Maintenance treatment for patients with major depressive disorder
- Treatment of generalized anxiety disorder
- Unlabeled use: Panic disorder
Alprazolam
Generic Name: alprazolam
Brand Name: Alprazolam Intensol, Apo-Alpraz (CAN), Niravam, Novo-Alprazol (CAN), Nu-Alpraz (CAN), Xanax, Xanax TS (CAN), Xanax XR
Other Info: Pregnancy Category D, Controlled Substance C-IV
Drug classes: Benzodiazepine, Anxiolytic
Therapeutic actionsExact mechanisms of action not understood; main sites of action may be the limbic system and reticular formation; increases the effects of GABA, an inhibitory neurotransmitter; anxiety blocking effects More >
Gabapentin
Brand Name: Apo-Gabapentin (CAN), Gen-Gabapentin (CAN), Neurontin
Other Info: Pregnancy Category C
Drug class: Antiepileptic
Therapeutic actionsMechanism of action not understood; antiepileptic activity may be related to its ability to inhibit polysynaptic responses and block posttetanic potentiation.
Indications- Adjunctive therapy in the treatment of partial seizures with and without secondary generalization in adults More >
Methylphenidate
Generic Name: methylphenidate hydrochloride
Brand Name: Apo-Methylphenidate (CAN), Concerta, Daytrana, Metadate CD, Metadate ER, Methylin, Methylin ER, PMS-Methylphenidate (CAN), Ritalin, Ritalin LA, Ritalin SR
Other Info: Pregnancy Category C, Controlled Substance C-II
Drug class: CNS stimulant
Therapeutic actionsMild cortical stimulant with CNS actions similar to those of the amphetamines; efficacy in hyperkinetic syndrome, attention-deficit disorders in children appearsparadoxical and is not understood
Indications- Ritalin, Ritalin SR, More >
Clonazepam
Generic Name: clonazepam
Brand Name: Apo-Clonazepam (CAN), Gen-Clonazepam (CAN), Klonopin, Klonopin Wafers, Nu-Clonazepam (CAN), Rivotril (CAN)
Other Info: Pregnancy Category X, Controlled Substance C-IV
Drug classes: Benzodiazepine, Antiepileptic
Therapeutic actionsExact mechanisms not understood; benzodiazepines potentiate the effects of GABA, an inhibitory neurotransmitter.
Indications- Used alone or as adjunct in treatment of Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures; may be useful in patients with absence (petit mal) More >
Buspirone HCl
Generic Name: buspirone hydrochloride
Brand Name: BuSpar
Pregnancy Category B
Drug class: Anxiolytic
Therapeutic actionsMechanism of action not known; lacks antiseizure, sedative, or muscle relaxant properties; binds serotonin receptors, but the clinical significance is unclear.
Indications- Management of anxiety disorders or short-term relief of symptoms of anxiety
- Unlabeled use: Decreasing the symptoms (aches, pains, fatigue, cramps, irritability) of More >
Amitriptyline HCl
Generic Name: amitriptyline hydrochloride
Brand Names: Endep (CAN), Tryptanol (CAN)
Pregnancy Category D
Drug class: TCA; tertiary amine
Therapeutic actionsMechanism of action unknown; TCAs inhibit the reuptake of the neurotransmitters norepinephrine and serotonin, leading to an increase in their effects; anticholinergicat CNS and peripheral receptors; sedative.
Indications- Relief of symptoms of depression (endogenous most responsive); sedative effects may help when depression is associated with anxiety More >
Lorazepam
Brand Names: Apo-Lorazepam (CAN), Ativan, Novo-Lorazem (CAN), Nu-Loraz (CAN)
Pregnancy Category D
Controlled Substance C-IV
Drug classes: Benzodiazepine, Anxiolytic, Sedative-hypnotic
Therapeutic actions
Exact mechanisms are not understood; acts mainly at subcortical levels of the CNS, leaving the cortex relatively unaffected. Main sites of action may be the limbic system and reticular formation; benzodiazepines potentiate the effects of GABA, an inhibitory neurotransmitter; anxiolytic effects occur at doses well below those More >
Lithium
lithium
Brand Names: Carbolith (CAN), Duralith (CAN), Eskalith, Eskalith CR, Lithane (CAN),
Pregnancy Category D
Drug class
Antimanic drug
Therapeutic actions
Mechanism is not known; alters sodium transport in nerve and muscle cells; inhibits release of norepinephrine and dopamine, but not serotonin, from stimulated neurons; slightly increases intraneuronal stores of catecholamines; decreases intraneuronal content of second messengers and may thereby selectively modulate the responsiveness of hyperactive neurons that might contribute to the More >
Diazepam
Generic Name: diazepam
Brand Names: Apo-Diazepam (CAN), Diastat, Diazemuls (CAN), Diazepam Intensol, Valium
Pregnancy Category D
Controlled Substance C-IV
Drug classes:
- Benzodiazepine
- Anxiolytic
- Antiepileptic
- Skeletal muscle relaxant (centrally acting)
Therapeutic actions
Exact mechanisms of action not understood; acts mainly at the limbic system and reticular formation; may act in spinal cord and at supraspinal sites to produce skeletal muscle relaxation; potentiates the effects of GABA, an inhibitory neurotransmitter; anxiolytic effects More >
