Blood Transfusion NCLEX Practice Quiz (15 Items)

Blood Transfusion NCLEX Practice Quiz (15 Items)

Assess your readiness for the NCLEX-RN examination by answering these practice questions about blood transfusion. In doing so will give you enough confidence to pass the test. This 15-item question about blood products and blood transfusion will definitely help you to do that.

Success seems to be connected with action. Successful people keep moving. They make mistakes, but they don’t quit.” ~ Conrad Hilton


Topics or concepts included in this exam are:

  • Administration of blood products (Packed red blood cells, fresh frozen plasma, platelet concentrate, and cryoprecipitate).
  • Blood transfusion


To make the most out of this quiz, follow the guidelines below:

  • Read each question carefully and choose the best answer.
  • You are given one minute per question. Spend your time wisely!
  • Answers and rationales (if any) are given below. Be sure to read them.
  • If you need more clarifications, please direct them to the comments section.


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Blood Transfusion and Administration of Blood Products NCLEX Practice Quiz (15 items)

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Blood Transfusion and Administration of Blood Products NCLEX Practice Quiz (15 items)

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1. Which nursing intervention takes highest priority when caring for a newly admitted client who’s receiving a blood transfusion?

A. Warming the blood prior transfusion.

2. Nurse Paulo has received a blood unit from the blood bank and has rechecked the blood bag properly with nurse Edward. Prior the facilitation of the blood transfusion, nurse Paulo priority check which of the following?

A. Intake and output.
B. NPO standing order.
C. Vital signs.
D. Skin turgor.

3. A client is brought to the emergency department having experienced blood loss due to a deep puncture wound. A 3 unit Fresh-frozen plasma (FFP) is ordered. The nurse determines that the reason behind this order is to:

A. Provide clotting factors and volume expansion.
B. Increase hemoglobin, hematocrit, and neutrophil levels.
C. Treat platelet dysfunction.
D. Treat thrombocytopenia.

4. Nurse Amanda is caring for a client with severe blood loss who is prescribed with multiple transfusion of blood. Nurse Amanda obtains which most essential piece of equipment to prevent the risk of cardiac dysrhythmias?

A. Cardiac monitor.
B. Blood warmer.
C. ECG machine.
D. Infusion pump.

5. A client is receiving a first-time blood transfusion of packed RBC. How long should the nurse stay and monitor the client to ensure a transfusion reaction will not happen?

A. 15 minutes.
B. 30 minutes.
C. 45 minutes.
D. 60 minutes.

6. Nurse Rick is administering a 2 unit packed RBC’s on a client with a low hemoglobin. The nurse will prepare which of the following in order to transfuse the blood?

A. Microfusion set.
B. Polyvol Pro Burette Set.
C. Photofusion set.
D. Tubing with an in-line filter.

7. To verify the age of blood cells in a blood, the nurse will check which of the following?

A. Blood type.
B. Blood group.
C. Blood identification number.
D. Blood expiration date.

8. A client has an order to receive a one unit of packed RBC’s. The nurse make sure which of the following intravenous solutions to hang with the blood product at the client’s bedside?

A. 0.9% sodium chloride.
B. 5% dextrose in 0.9% sodium chloride.
C. Balanced Multiple Maintenance Solution with 5% Dextrose.
D. 5% dextrose in 0.45% sodium chloride.

9. Nurse Jay is caring for a client with an ongoing transfusion of packed RBC’s when suddenly the client is having difficulty of breathing, skin is flushed and having chills. Which action should nurse Jay take first?

A. Administer oxygen.
B. Place the client on droplight.
C. Check the client’s temperature.
D. Stop the transfusion.

10. After terminating the transfusion during a reaction, which action should the nurse immediately be taken next? 

A. Run a solution of 5% dextrose in water.
B. Run normal saline at a keep-vein-open rate.
C. Remove the IV line.
D. Fast drip 200ml normal saline.

11. A client is receiving a platelet transfusion. The nurse determines that the client is gaining from this therapy if the client exhibits which of the following? 

A. Less frequent febrile episodes.
B. Increased level of hematocrit.
C. Less episodes of bleeding.
D. Increased level of hemoglobin.

12. Nurse Daniel is caring for a client receiving a transfusion of packed red blood cells (PRBCs). The client started to vomit and to be nauseous. Client’s blood pressure is 95/40 mm Hg from a baseline of 110/70 mm Hg. The client’s temperature is 100.5°F orally from a baseline of 99.5°F orally. The nurse understand that the client may be experiencing which of the following?

A. Circulatory overload.
B. Delayed transfusion reaction.
C. Hypocalcemia.
D. Septicemia.

13. Packed red blood cells have been prescribed for a client with low hemoglobin and hematocrit levels. The nurse takes the client’s temperature before hanging the blood transfusion and records 100.8 °F. Which action should the nurse take?

A. Give an antipyretic and begin the transfusion.
B. Proceed with the transfusion.
C. Administer an antihistamine and begin the transfusion.
D. Delay hanging the blood and inform the physician.

14. A nurse is caring for a client requiring surgery and is ordered to have a standby blood secured if in case a blood transfusion is needed during or after the procedure. The nurse suggest to the client to do which of the following to lessen the risk of possible transfusion reaction? 

A. Request that any donated blood be screened twice by the blood bank.
B. Take iron supplement prior the surgery and eat green leafy vegetables.
C. Do an autologous blood donation.
D. Have a family member donate their own blood.

15. A client is receiving transfusion of one unit of cryoprecipitate. The nurse will review which of the following laboratory studies to assess the effectiveness of the therapy? 

A. Serum electrolytes.
B. White blood cell count.
C. Coagulation studies.
D. Hematocrit count.

Answers and Rationale

1. Answer: D. Instructing the client to report any itching, headache, or dyspnea.

This will help the nurse take immediate action incase a reaction happens during a transfusion.

2. Answer: C. Vital signs.

The nurse must assess the vital signs before and 15 minutes after the procedure so that any changes during the transfusion may indicate a transfusion reaction is happening.

3. Answer: A. Provide clotting factors and volume expansion.

Fresh-frozen plasma may be used to provide clotting factors or volume expansion. It is rich in clotting factors and can be thawed quickly and transfused right away.

  • Option B is incorrect since it will not specifically increase the hemoglobin, hematocrit, and neutrophil level.
  • Options C and D are incorrect since FFP does not contain any platelet.

4. Answer: B. Blood warmer.

Rapid transfusion of cool blood put the client at risk for cardiac dysrhythmias.

  • Options A and C are used to assess for any blood transfusion-related complication, but they do not prevent the occurrence of cardiac dysrhythmia.
  • Option D is not beneficial in this case since the infusion must be given rapidly.

5. Answer: A. 15 minutes.

Usually, a transfusion reaction occurs within the 15 minutes of a transfusion.

6. Answer: D. Tubing with an in-line filter.

The in-line filter helps ensure that any particles larger than the size of the filter are caught in the filter and are not infused with the client.

  • Option A is incorrect since the tubing that should be used is a macro drip.
  • Option B is used for administration of IV medication infusion.
  • Option C is incorrect since blood does not need any protection from light.

7. Answer: D. Blood expiration date.

The safe storage of blood usually takes 35 days. Examining the expiration date is an important responsibility of a nurse prior hanging the blood.

8. Answer: A. 0.9% sodium chloride.

0.9% sodium chloride is a standard solution used to follow infusion of blood products.

  • Options B, C, and D: IV solution containing dextrose in water will hemolyze red cells.

9. Answer: D. Stop the transfusion.

The client in this situation is experiencing transfusion reaction so the priority action of the nurse is to first stop the transfusion.

10. Answer: B. Run normal saline at a keep-vein-open rate.

The nurse will infuse normal saline at a KVO rate to keep the patency of the IV line while waiting for further orders from the physician.

  • Option A: IV solution containing dextrose will hemolyze the red cells.
  • Option C: The nurse will not remove the IV line because then there would be no IV access route.
  • Option D: Doing a fast drip will potentially lead to congestion and is not done without the physician order.

11. Answer: C. Less episodes of bleeding.

Platelet transfusions may be given to prevent bleeding when the platelet count falls down.

  • Option A: A decline in the febrile episode will happen after the transfusion of agranulocytes.
  • Options B and D: An increased level of hemoglobin and hematocrit will happen after the transfusion of red blood cells.

12. Answer: D. Septicemia.

Septicemia happens with the transfusion of blood that is contaminated with microorganisms. Assessment includes rapid onset of high fever and chills, hypotension, nausea, diarrhea, vomiting, and shock.

  • Option A: Circulatory overload causes hypertension, cough, dyspnea, chest pain, tachycardia, and wheezing upon auscultation.
  • Option B: Delayed reaction can occur days to years after a transfusion. It causes, fever, rashes, mild jaundice, and oliguria or anuria.
  • Option C: Hypocalcemia causes paresthesias, tetany, muscle cramps, hyperactive reflexes, positive Trousseau’s sign, and positive Chovstek’s sign.

13. Answer: D. Delay hanging the blood and inform the physician.

If the client has a temperature higher than 100 ° F, the unit of blood should be hung and delayed until the physician is notified and has the opportunity to give further order.

  • Options A and C are incorrect since the administration of the medicine will need the physician’s prescription.
  • Option B: The decision to administer the blood is not within the scope of nurse practice.

14. Answer: C. Do an autologous blood donation.

A donation of the own blood is autologous. Doing this will prevent the risk of transfusion reaction.

15. Answer: C. Coagulation studies.

The evaluation of an effective response of a cryoprecipitate transfusion is assessed by monitoring coagulation studies and fibrinogen levels.

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Paul Martin is a registered nurse with a bachelor of science in nursing since 2007. Having worked as a medical-surgical nurse for five years, he handled different kinds of patients and learned how to provide individualized care to them. Now, his experiences working in the hospital is carried over to his writings to help aspiring students achieve their goals. He is currently working as a nursing instructor and have a particular interest in nursing management, emergency care, critical care, infection control, and public health. As a writer at Nurseslabs, his goal is to impart his clinical knowledge and skills to students and nurses helping them become the best version of themselves and ultimately make an impact in uplifting the nursing profession.


  1. thank you, these questions will help me facilitated drill questions that would enhance my students background knowledge, your name will be acknowledged


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