Antiarthritic Drugs Nursing Pharmacology Study Guide

Antiarthritic drugs include gold compounds that prevent and suppress arthritis in selected patients with rheumatoid arthritis and other anti arthritis drugs that helps block the inflammation and tissue damage of rheumatoid arthritis.

Table of Common Drugs and Generic Names


Here is a table of commonly encountered immune system drugs, their generic names, and brand names:

Classification Generic Name Brand Name
Gold Compounds auranofin Ridaura
gold sodium thiomalate Aurolate
Other Agents anakinra Kineret
etanercept Enbrel
hyaluronidase derivatives Synvisc
penicillamine Depen
sodium hyaluronate Hyalgan

Disease Spotlight: Arthritis


  • Arthritis is a group of more than 100 types of joint pain or disease and related conditions involving inflammatory process in the joints which can cause pain and bone It affects people of all ages, sexes, and races. It is the leading cause of disability in America.
  • Symptoms include swelling, pain, stiffness, and decreased range of motion. Over time, this will lead to permanent joint changes.
  • NSAIDs are often used in rheumatoid arthritis (an autoimmune disorder affecting the small joints) and osteoarthritis (arthritis of the weight-bearing joints common in older people).

Gold Compounds


Description

  • Gold salts treatment (chrysotherapy) is indicated for patients with rheumatic inflammatory conditions who do not respond to the usual anti-inflammatory therapies. Chrysotherapy involves macrophages taking up gold which then inhibit phagocytosis.

Therapeutic Action

The desired and beneficial action of gold compounds is:

  • Inhibition of phagocytosis and release of lysosomal enzymes leading to inhibited tissue destruction. This action allows gold salts to suppress and prevent some arthritis and synovitis.

Indications

Gold compounds are indicated for the following medical conditions:

  • Treatment for selected cases of rheumatoid and juvenile rheumatoid arthritis in patients whose disease have been unresponsive to standard therapy. However, they only prevent further damage and so are most effective if used early in the disease.
  • Auranofin is an oral agent for long-term therapy of rheumatic disorders.
  • Gold sodium thiomalate is an injected drug for early treatment of rheumatic disorders.

Pharmacokinetics

Here are the characteristic interactions of gold compounds and the body in terms of absorption, distribution, metabolism, and excretion:

Route Onset Peak Duration
Oral Slow 4-6 h
T1/2: 3-7 days
Metabolism: –
Excretion: urine and feces

Contraindications and Cautions

The following are contraindications and cautions for the use of gold compounds:

Adverse Effects

Use of gold compounds may result to these adverse effects:

  • Skin: dermatitis, pruritus, exfoliative dermatitis, allergic reactions ranging from flushing, fainting, and dizziness to anaphylactic shock
  • GI: stomatitis, glossitis, gingivitis, pharyngitis, laryngitis, colitis, diarrhea, other GI inflammation
  • Respiratory: gold bronchitis, interstitial pneumonitis
  • Hema: bone marrow depression
  • GU: vaginitis, nephrotic syndrome

Interactions

The following are drug-drug interactions involved in the use of gold compounds:

  • Penicillamine, antimalarials, cytotoxic drugs, immunosuppressive agents: potential for severe toxicity

Nursing Considerations

Nursing considerations for patients receiving antiarthritics are similar to those for patients receiving nonsteroidal anti-inflammatory drugs and related agents.

Practice Quiz: Antiarthritic Agents


Here are some practice questions for this study guide:

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1. How can antiarthritic drugs suppress some arthritis?

A. by suppressing autoantibodies produced by the body
B. by inhibiting phagocytosis and release of lysosomal enzymes
C. by coating the inflamed site and promoting healing
D. all of the above

1. Answer: B. These actions inhibit tissue destruction.

2. Which antiarthritic is an oral agent for long-term therapy of rheumatic disorders?

A. anakinra
B. allopurinol
C. auranofin
D. gold sodium thiomalate

2. Answer: C. auranofin

3. Gold compounds can be very toxic. This should be avoided in all of the following patients, except:

A. Asthma
B. Congestive heart failure
C. Severe diabetes
D. A and C only

3. Answer: A. Asthma

Options B and C are contraindicated for use of gold compounds.

4. Which of the following is/are true about gold compounds?

A. This is the first line agent for treatment of arthritis.
B. Gold compounds can cause interstitial pneumonitis.
C. It is safe for geriatric patients.
D. All of the above

4. Answer: B. Gold compounds can cause interstitial pneumonitis.

Two respiratory adverse effects of gold compounds are gold bronchitis and interstitial pneumonitis. It can be particularly toxic to geriatric patients and can lead to GI, renal, and hepatic adverse effects. This is only indicated for patients unresponsive to conventional therapy.

5. This is an injected drug for early treatment of rheumatic disorders.

A. anakinra
B. allopurinol
C. auranofin
D. gold sodium thiomalate

5. Answer: D. gold sodium thiomalate

See Also


Here are other nursing pharmacology study guides:

Endocrine System Drugs

Autonomic Nervous System Drugs

Immune System Drugs

Chemotherapeutic Agents

Reproductive System Drugs

Nervous System Drugs

Cardiovascular System Drugs

Further Reading and Resources


Recommended resources and books:

  1. Focus on Nursing Pharmacology - Easy to follow guide for Pharmacology
  2. NCLEX-RN Drug Guide: 300 Medications You Need to Know for the Exam - Great if you're reviewing for the NCLEX
  3. Nursing 2017 Drug Handbook (Nursing Drug Handbook) - Reliable nursing drug handbook!
  4. Lehne's Pharmacology for Nursing Care - Provides key information on commonly used drugs in nursing
  5. Pharmacology and the Nursing Process - Learn how to administer drugs correctly and safely!
  6. Pharm Phlash Cards!: Pharmacology Flash Cards - Flash Cards for Nursing Pharmacology